Tenofovir reduces mother-to-child transmission of hepatitis B: new study

WHO/Y. Shimizu

16 June 2016 – New study findings published today confirm that antiviral therapy with tenofovir in late pregnancy can result in a 3-fold reduction in mother-to-child transmission (MTCT) of hepatitis B virus (HBV), when used in combination with immunoglobulin and HBV vaccine at birth. "The new findings show that antiviral therapy will have an important future role in elimination of MTCT of hepatitis B, especially in women with high levels of virus," said Dr Gottfried Hirnschall, Director of the World Health Organization’s (WHO) HIV/AIDS Department and Global Hepatitis Programme. "WHO will update its HBV guidelines in view of the growing evidence, as well as help address challenges in putting this into practice in different parts of the world.”

What is viral hepatitis

Viral hepatitis is an inflammation of the liver caused by one of the five hepatitis viruses: A, B, C, D and E. The five hepatitis viruses are transmitted through different routes: hepatitis A and E through contaminated food and water; hepatitis B through blood and other bodily fluids; hepatitis C and D mostly through blood. These viruses can all cause acute hepatitis. Most people fully recover from acute infection. However, hepatitis B and C infection can lead to chronic liver disease, which is the most common cause of liver cirrhosis and liver cancer. Each year, 1.4 million people die from the various forms of viral hepatitis worldwide.

Preventing and treating viral hepatitis

Hepatitis can be prevented by providing safe food and water (hepatitis A and E), through vaccination (hepatitis A, B, D and E), screening of blood donations, provision of sterile injecting equipment (hepatitis B and C) and appropriate infection control. Chronic hepatitis B and C infections can be treated, but most people, especially those living in low- and middle-income countries, do not have access to treatment because of lack of diagnostic and clinical services and high prices of some of the antiviral hepatitis medicines.

Viral hepatitis in the Western Pacific Region

The WHO Western Pacific Region bears a disproportionally high burden of hepatitis compared to other Regions: although it is home to a quarter of the world’s population, it accounts for about 50% of hepatitis B-related deaths worldwide. Of the 130-150 million people worldwide who are chronically infected with hepatitis C, more than 60 million live in this Region. The Western Pacific Region accounts for more than 60% of global liver cancer cases, the majority of which are caused by chronic hepatitis B or C.

fact buffet

Hepatitis B

115 millionpeople are living with chronic hepatitis B in the Western Pacific Region (2016 estimate)

Hepatitis C

14 millionpeople are living with chronic hepatitis C in the Western Pacific Region (2016 estimate)

Hepatitis C

150 000people with chronic hepatitis C infection are treated in Western Pacific Region in 2015